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Rhino-orbito-cerebral mucormycosis is a rare opportunistic invasive fungal infection, with rapid progression and high mortality. It is characterized by an aggressive necrotizing infection spreading from the nose to the paranasal sinuses, orbit, and the brain. This disease is often associated with diabetic ketoacidosis, leukemia, malnutrition, AIDS and immunocompromis ed patients. Typical initial symptoms of a patient with rhino-orbito-cerebral mucormycosis are facial pain and swelling, headache, fever, and blood-tinged rhinorrhea. Symptoms rapidly progressed to facial or orbital cellulitis, proptosis, and visual loss, facial nerve palsy. We report a case report of a 66-year-old woman with poorly controlled diabetes mellitus who developed mucormycosis which involved unilateral paranasal sinus, orbit, and selective cranial nerves.
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